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Kerafast/Anti-ADAM28 (mouse), Extracellular Domain Antibody/EHS012/100uL
ThisrabbitIgGpolyclonalantibodywasgeneratedagainsttheentireectodomainofADAM28includingtheEGFrepeatfusedtotheFcdomainofhumanIgGandisspecificfortheextracellulardomainofmouseADAM28.
TheADAM(ADisintegrinAndMetalloproteaseDomain)familyisauniquegroupofproteinsthathastheABIlitytocleaveorshedextracellularportionsoftransmembraneproteins.Inaddition,ADAMsareinvolvedincell-cellandcell-matrixinteractions(e.g.,fertilization,muscledevelopmentandneurogenesis).
Basedonsequenceidentity,ADAM28ismorecloselyrelatedtosnakevenommetalloproteases(SVMPs)thantopresentlyknownADAMs.NorthernblotanalysisrevealedADAM28isexpressedintheepididymis,suggestingapossIBLeroleinspermmaturation,andinthelung.MatureADAM28ispresumedtobecatalyticallyactiveandfoundmainlyonthecellsurface.
FromthelaboratoryofCarlP.Blobel,MD,PhD,HospitalforSpecialSurgery.
| ProductType: | Antibody |
| AccessionID: | AF153350 |
| Antigen: | GST-ADAM28CytoplasmicDomain |
| MolecularWeight: | ~100kDa |
| Isotype: | IgG |
| Clonality: | Polyclonal |
| Reactivity: | Mouse |
| Immunogen: | EntireectodomainofmouseADAM28includingtheEGFrepeatfusedtotheFcdomainofhumanIgG1 |
| SpeciesImmunized: | Rabbit |
| Epitope: | Extracellulardomain |
| PurificationMethod: | Serum,notpurified |
| TestedApplications: | WB(1:500),onlyonnon-reducedsamples(noDTTorBME) |
| Storage: | -80C |
| Shipped: | Dryice |
| Antibody | SpeciesReactivity | Specificity |
| ADAM9 | Human | CytoplasmicDomain |
| ADAM9 | Mouse | CytoplasmicDomain |
| ADAM12 | Mouse | CytoplasmicDomain |
| ADAM15 | Human | CytoplasmicDomain |
| ADAM15 | Mouse | CytoplasmicDomain |
| ADAM15 | Human | ExtracellularDomain |
| ADAM15 | Mouse | DisintegrinDomain |
| ADAM17 | Mouse | CytoplasmicDomain |
| ADAM17 | Mouse | Prodomain |
| ADAM19 | Mouse | CytoplasmicDomain |
| ADAM28 | Mouse | CytoplasmicDomain |
| ADAM28 | Mouse | ExtracellularDomain |
| SNX9 | Mouse | CytoplasmicDomain |
- Howard,L.;Zheng,Y.;Horrocks,M.;Maciewicz,R.A.;Blobel,C.CatalyticactivityofADAM28.FEBSLett.2001,498,82-86.
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