ThisrabbitIgGpolyclonalantibodywasgeneratedagainsttheGST-ADAM12-cytoplasmictailandisspecificforthecytoplasmicdomainofmouseADAM12.
TheADAM(ADisintegrinAndMetalloproteaseDomain)familyisauniquegroupofproteinsthathastheABIlitytocleaveorshedextracellularportionsoftransmembraneproteins.Inaddition,ADAMsareinvolvedincell-cellandcell-matrixinteractions(e.g.,fertilization,muscledevelopmentandneurogenesis).
LiketheotherADAMmembers,ADAM12isstructurallyrelatedtosnakevenomdisintegrins.Ithastwoalternativelysplicedtranscripts:ashortersecretedformandalongermembrane-boundform.ADAM12hasbeenimplicatedinbreastandprostatecancer.
FromthelaboratoryofCarlP.Blobel,MD,PhD,HospitalforSpecialSurgery.
PartofTheInvestigator"sAnnexeprogram.
| ProductType: | Antibody |
| Antigen: | GST-ADAM12cytoplasmicdomain |
| AccessionID: | D50411 |
| Isotype: | IgG |
| Clonality: | Polyclonal |
| Reactivity: | Mouse |
| Immunogen: | GST-cytocorrespondingtothecytoplasmicdomainofmouseADAM12 |
| SpeciesImmunized: | Rabbit |
| Epitope: | Cytoplasmicdomain |
| PurificationMethod: | Serum,notpurified |
| TestedApplications: | WB(1:500) |
| Storage: | -80C |
| Shipped: | Dryice |
| Antibody | SpeciesReactivity | Specificity |
| ADAM9 | Human | CytoplasmicDomain |
| ADAM9 | Mouse | CytoplasmicDomain |
| ADAM12 | Mouse | CytoplasmicDomain |
| ADAM15 | Human | CytoplasmicDomain |
| ADAM15 | Mouse | CytoplasmicDomain |
| ADAM15 | Human | ExtracellularDomain |
| ADAM15 | Mouse | DisintegrinDomain |
| ADAM17 | Mouse | CytoplasmicDomain |
| ADAM17 | Mouse | Prodomain |
| ADAM19 | Mouse | CytoplasmicDomain |
| ADAM28 | Mouse | CytoplasmicDomain |
| ADAM28 | Mouse | ExtracellularDomain |
| SNX9 | Mouse | CytoplasmicDomain |
- Inoue,D.;Reid,M.;Lum,L.;Krätzschmar,J.;Weskamp,G.;Myung,Y.M.;Baron,R.;Blobel,C.P.Cloningandinitialcharacterizationofmousemeltrinbetaandanalysisoftheexpressionoffourmetalloprotease-disintegrinsinbonecells.J.Biol.Chem.1998,273,4180-4187.
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